Will there be light at the end of this tunnel?

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mechanisms of bax/bak activation: is there any light at the end of the tunnel?

in this review we summarize the current knowledge on the mechanisms by which the pore-forming bcl-2 family members bax and bak are activated on the mitochondrial outer membrane (mom) in apoptotic cells. we compare the two major working models and conclude that they are both insufficient to explain reality. instead, we need to identify novel binding partners and posttranslational modifications o...

End-stage renal disease epidemic in diabetics: is there light at the end of the tunnel?

1. Briganti EM, Russ GR, McNeil JJ et al. Risk of renal allograft loss from recurrent glomerulonephritis. N Engl J Med 2002; 347: 103–109 2. Odum J, Peh CA, Clarkson AR et al. Recurrent mesangial IgA nephritis following renal transplantation. Nephrol Dial Transplant 1994; 9: 309–312 3. Ortiz F, Gelpi R, Koskinen P et al. IgA nephropathy recurs early in the graft when assessed by protocol biopsy...

Can the laser light at the end of the tunnel be used to get to the end of the tunnel?

[1] Otsuka Y, Miyazaki S, Okumara H et al. Abnormal glucose tolerance, not small vessel diameter, is a determinant of longterm prognosis in patients treated with balloon angioplasty. Eur Heart J 2000; 21: 1790–96. [2] Fuller JH, Shipley M, Rose G, Jarrett RJ, Keen H. Mortality from coronary heart disease and stroke in relation to degree of glycaemia: The Whitehall Study. BMJ 1983; 287: 867–70. ...

Knowing Afghanistan: Can there be an end to the saga?

War on terrorism, as the motto which formed the cornerstone of global policies of former     neo-conservative administration of the United States, is increasingly becoming ineffective in Afghanistan with the dreaded consequence of spilling over into Pakistan. This inevitable consequence of War on    Terrorism in Afghanistan has brought the West face to face with the ‘nest of terrorism’ that CIA...